Huntington's disease.

Behavioral study of effects of mesenchymal stem cells transplant on motor deficits improvement in animal model of Huntington\'s disease

Introduction: As an inherited neurodegenerative disease, Huntington's disease is accompanied with wide neuronal degeneration in neostriatum and neocortex. Progress of the disease causes disabling clinical effects on movements, recognition and physiology of the body, and finally results in death. At this stage of knowledge we are, there is no effective therapeutic strategy for diminishing the mo...

Evidence for specific cognitive deficits in preclinical Huntington's disease.

The performance of 54 subjects genetically at risk for Huntington's disease was examined in double-blind fashion on a series of computerized tests from the Cambridge Neuropsychological Test Automated Battery. None of the subjects exhibited clinical movement disorder characteristic of Huntington's disease. Of the 54 subjects, 22 were Huntington's disease mutation carriers and 32 were non-carrier...

Plasma melatonin is reduced in Huntington's disease.

This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduc...

Upcoming Meetings Related to Huntington's Disease.

Cardiac Dysautonomia in Huntington's Disease.

Huntington's disease is a fatal, hereditary, neurodegenerative disorder best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances. Although a disease of the central nervous system, mortality surveys indicate that heart disease is a leading cause of death. The nature of such cardiac abnormalities remains unknown. Clinical findings indicate...

Neuropsychiatric aspects of Huntington's disease.

OBJECTIVE Neuropsychiatric symptoms are common in Huntington's disease and have been considered its presenting manifestation. Research characterising these symptoms in Huntington's disease is variable, however, encumbered by limitations within and across studies. Gaining a better understanding of neuropsychiatric symptoms is essential, as these symptoms have implications for disease management,...